The Pirates of the Caribbean star never gets sick while he is working, but as soon as he finishes each job he comes down with a mystery ailment which keeps him in bed for weeks at a time.

And Depp is convinced he over-exerts himself while he is acting.

He says, "There is a period once you finish a guy - a character - when you're looking to go back to yourself and sometimes it can manifest itself in illness. After I made The Libertine, I was in bed for two weeks. When you're working, you don't get sick, then suddenly it hits you like a two-by-four."

Source: WENN