The former talk show host won 44 per cent of the vote in the survey conducted by U.S. publication, Parade, with second place going to Paris Hilton.
But O'Donnell is unimpressed by the dubious honour - despite agreeing with the sentiment of the poll, according to celebrity blogger Perez Hilton.
She says, "I apparently am the most annoying celebrity. And, frankly, most celebrities are annoying. So, I agree.
"Celebrities are annoying and the fact that I am one is annoying. And I suppose I am the most annoying."
Source: WENN